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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches …
T. Lohoff, S. Ghazanfar, A. Missarova, N. Koulena, N. Pierson, J. A. Griffiths, E. S. Bardot, C.-H. L. Eng, R. C. V. Tyser, R. Argelaguet, C. Guibentif, S. Srinivas, J. Briscoe, B. D. Simons, A.-K. Hadjantonakis, B. Göttgens, W. Reik, J. Nichols, L. Cai, J. C. Marioni
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Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction
Background: There is considerable interest in whether genetic data can be used to improve standard cardiovascular disease risk …
Fernando Riveros-Mckay, Michael E. Weale, Rachel Moore, Saskia Selzam, Eva Krapohl, R. Michael Sivley, William A. Tarran, Peter Sørensen, Alexander S. Lachapelle, Jonathan A. Griffiths, Ayden Saffari, John Deanfield, Chris C.A. Spencer, Julia Hippisley-Cox, David J. Hunter, Jack W. O’Sullivan, Euan A. Ashley, Vincent Plagnol, Peter Donnelly
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Diverse Routes toward Early Somites in the Mouse Embryo
Somite formation is foundational to creating the vertebrate segmental body plan. Here, we describe three transcriptional trajectories …
Carolina Guibentif, Jonathan A. Griffiths, Ivan Imaz-Rosshandler, Shila Ghazanfar, Jennifer Nichols, Valerie Wilson, Berthold Göttgens, John C. Marioni
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A single-cell molecular map of mouse gastrulation and early organogenesis
Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into …
Blanca Pijuan-Sala, Jonathan A. Griffiths, Carolina Guibentif, Tom W. Hiscock, Wajid Jawaid, Fernando J. Calero-Nieto, Carla Mulas, Ximena Ibarra-Soria, Richard C. V. Tyser, Debbie Lee Lian Ho, Wolf Reik, Shankar Srinivas, Benjamin D. Simons, Jennifer Nichols, John C. Marioni, Berthold Göttgens
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Detection and removal of barcode swapping in single-cell RNA-seq data
DNA barcode swapping results in mislabelling of sequencing reads between multiplexed samples. Here, the authors investigate the …
Jonathan A. Griffiths, Arianne C. Richard, Karsten Bach, Aaron T. L. Lun, John C. Marioni
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Using single‐cell genomics to understand developmental processes and cell fate decisions
High‐throughput ‐omics techniques have revolutionised biology, allowing for thorough and unbiased characterisation of the molecular …
Jonathan A. Griffiths, Antonio Scialdone, John C. Marioni
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Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data
Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human …
Jonathan A. Griffiths, Antonio Scialdone, John C. Marioni
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