Bio

I am the CTO at Cyclana Bio, where I lead our computational efforts. This role is very wide-ranging, covering our computational science (-omics and human genetics), alongside more technical and engineering-focused aspects like our cloud and on-premises infrastructure, our EDC software for observational clinical trials, and all of our data ingest, storage, and processing.

I am unusually interdisciplinary, having acquired deep expertise in biology, functional genomics, human genetics, and machine learning, all the while developing a robust, engineering mindset. I am most effective when working across these areas, and I have found that modern AI tools have made it possible for tiny teams to execute strongly across the whole lot.

In the past:

• I have led a machine learning team at Altos Labs in its Institute of Computation, developing large language models for epigenetics.
• I identified and developed therapeutic stories for novel targets for therapeutic intervention in SLE, based on human genetic association and genomics data, at Genomics.
  • In a short return stint there, I designed and prototyped their gene expression platform for Mystra, and developed the first version of their AI agent.
• I consulted for bit.bio in the earliest stages of their existence, where I developed gene expression evidence that helped them win their first research grants.
• I pioneered the first analyses of large-scale single-cell RNA-sequencing data during my PhD in John Marioni’s lab.

Education

• PhD - Marioni Lab, University of Cambridge, 2015-19
• BSc, Natural Sciences - Molecular and Cell Biology, with Atomic and Particle Physics. University College London, 2012-15